A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Archive ouverte

Castagné, Raphaële | Kelly-Irving, Michelle | Krogh, Vittorio | Palli, Domenico | Panico, Salvatore | Sacerdote, Carlotta | Tumino, Rosario | Hebels, Dennie Gaj | Kleinjans, Jos CS | de Kok, Theo MCM | Georgiadis, Panagiotis | Kyrtopoulos, Soterios, A | Vermeulen, Roel | Stringhini, Silvia | Vineis, Paolo | Chadeau-Hyam, Marc | Delpierre, Cyrille

Edité par CCSD ; Future Medicine (Taylor & Francis) -

International audience. Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion