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Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

Archive ouverte | Pottier, Cyril | CCSD

International audience. Background Loss-of-function mutations in progranulin (GRN) cause frontotemporal dementia. Patients with GRN mutations present with a uniform subtype of TDP-43 pathology at autopsy (FTLD-TDP t...

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Archive ouverte | de Rojas, Itziar | CCSD

International audience. Abstract Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and eff...

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Archive ouverte | Swarup, Vivek | CCSD

International audience. Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the ...

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