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Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia

Archive ouverte | Lopez, Cecile | CCSD

International audience

The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300‐dependent stemness program

Archive ouverte | Fagnan, Alexandre | CCSD

International audience. Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in...

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.

Archive ouverte | Fagnan, Alexandre | CCSD

International audience. Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes ...

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