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Assessment of t-cell polarization on the basis of surface marker expression: diagnosis and potential therapeutic implications in lymphocytic variant hypereosinophilic syndrome

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Ledoult, Emmanuel | Groh, Matthieu | Kahn, Jean-Emmannuel | Trauet, Jacques | Bouaziz, Jean-David | Caristan, Aurelie | Cottin, Vincent | Dubucquoi, Sylvain | Etienne, Nicolas | Golden, Cecile | Guillaume-Jugnot, Perrine | Hachulla, Eric | Launay, David | Machelart, Irene | de Masson, Adele | Molinet, Thomas | Morati-Hafsaoui, Chafika | Puget, Marie | Roumier, Mathilde | Terriou, Louis | Meresse, Bertrand | Dendooven, Arnaud | Copin, Marie-Christine | Dubois, Romain | Labalette, Myriam | Lefevre, Guillaume

Edité par CCSD ; Elsevier / American Academy of Allergy, Asthma & Immunology / American Academy of Allergy, Asthma and Immunology -

International audience. Lymphocytic variant hypereosinophilic syndrome (LHES)-associated CD3−CD4+ T cells in blood homogeneously express chemokine receptors associated with TH2 polarization (CCR6−CCR4+)—even if the patients are treated with steroids. New treatment strategies such as CRTh2 antagonists and anti-CCR4 antibody could be considered in severe LHES.

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