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Monocytes generated by interleukin-6-treated human hematopoietic stem and progenitor cells secrete calprotectin that inhibits erythropoiesis

Archive ouverte | Marchand, Valentine | CCSD

International audience. Highlights d IL-6 promotes the generation of monocytes secreting calprotectin d Calprotectin inhibits erythroid progenitor differentiation d JAK2-V617F amplifies hematopoietic effects of calp...

Inferring the dynamic of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Archive ouverte | Mosca, Matthieu | CCSD

International audience. Classical BCR-ABL-negative myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells (HSC) caused mainly by recurrent mutations in genes encoding JAK2 (JAK2), calret...

CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia

Archive ouverte | Deschamps, Paul | CCSD

International audience. Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy with limited therapeutic options. Single-cell analysis of clonal architecture demonstrates early clonal dominance with fe...

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