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Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

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Fenwick, Craig | Turelli, Priscilla | Duhoo, Yoan | Lau, Kelvin | Herate, Cécile | Marlin, Romain | Lamrayah, Myriam | Campos, Jérémy | Esteves-Leuenberger, Line | Farina, Alex | Raclot, Charlène | Genet, Vanessa | Fiscalini, Flurin | Cesborn, Julien | Perez, Laurent | Dereuddre-Bosquet, Nathalie | Contreras, Vanessa | Lheureux, Kyllian | Relouzat, Francis | Abdelnabi, Rana | Leyssen, Pieter | Lévy, Yves | Pojer, Florence | Le Grand, Roger | Trono, Didier | Pantaleo, Giuseppe

Edité par CCSD ; Elsevier -

International audience. Highlights: • Anti-SARS-CoV-2 neutralizing antibody with ACE2 mimetic binding properties • Broad-spectrum activity against all past and current SARS-CoV-2 variants of concern • Mutations escaping mAb activity bind ACE2 poorly and are rare in circulating virus • Sterilizing protection from XBB.1.5 infection in an NHP challenge model †These authors contributed equally and ‡ authors contributed equally.

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