Different Genetic Signatures of Small‐Cell Lung Cancer Characterize Anti‐GABA_BR and Anti‐Hu Paraneoplastic Neurological Syndromes

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Vogrig, Alberto | Pegat, Antoine | Villagrán‐garcía, Macarena | Wucher, Valentin | Attignon, Valéry | Sohier, Emilie | Brevet, Marie | Rogemond, Veronique | Pinto, Anne‐laurie | Muñiz‐castrillo, Sergio | Peter, Elise | Robert, Melisse | Picard, Géraldine | Hopes, Lucie | Psimaras, Dimitri | Terra, Anthony | Perrin, Corinne | Cogne, Dominique | Tabone-Eglinger, Séverine | Martinez, Séverine | Jury, Delphine | Valantin, Julie | Gadot, Nicolas | Auclair‐perrossier, Jessie | Viari, Alain | Dubois, Bertrand | Desestret, Virginie | Honnorat, Jérôme

Edité par CCSD ; Wiley -

International audience. Objective: Small-cell lung cancer (SCLC) is the malignancy most frequently associated with paraneoplastic neurological syndromes (PNS) and can trigger different antibody responses against intracellular (Hu) or neuronal surface (GABA B R) antigens. Our aim was to clarify whether the genomic and transcriptomic features of SCLC are different in patients with anti-GABA B R or anti-Hu PNS compared with SCLC without PNS. Methods: A total of 76 SCLC tumor samples were collected: 34 anti-Hu, 14 anti-GABA B R, and 28 SCLC without PNS. The study consisted of 4 steps: (1) pathological confirmation; (2) next generation sequencing using a panel of 98 genes,

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