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Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions

Archive ouverte | Wang, Shaoying | CCSD

International audience. To investigate the impact of paracrine IL-2 signals on memory precursor (MP) cell differentiation, we activated CD8 T cell in vitro in the presence or absence of exogenous IL-2 (ex-IL-2). We ...

Antigen specific activation of cytotoxic CD8+ T cells by Staphylococcus aureus infected dendritic cells

Archive ouverte | Friot, Adèle | CCSD

International audience. Staphylococcus aureus ( S. aureus ) is a pathogen associated with a wide variety of diseases, from minor to life-threatening infections. Antibiotic-resistant strains have emerged, leading to ...

A temporary challenge by tumor cells can lead to a permanent partial-impairment of memory CD8 T cell function

Archive ouverte | Laubreton, Daphné | CCSD

Memory CD8 T cells typically exhibit improved effector functions compared to their naive counterparts. However, under certain activation conditions, such as chronic viral infections or cancer, these cells may develop functional de...

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