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Phosphorylation of spinal N‐methyl‐ d ‐aspartate receptor NR1 subunits by extracellular signal‐regulated kinase in dorsal horn neurons and microglia contributes to diabetes‐induced painful neuropathy

Archive ouverte | Daulhac, Laurence | CCSD

International audience. Abstract The N‐methyl‐ d ‐aspartate receptor (NMDAR) contributes to central sensitization in the spinal cord, a phenomenon which comprises various pathophysiological mechanisms responsible fo...

Acetaminophen recruits spinal p42/p44 mAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system

Archive ouverte | Bonnefont, Jérôme | CCSD

International audience. The mechanism of action of acetaminophen is currently widely discussed. Direct inhibition of cyclooxygenase isoforms remains the commonly advanced hypothesis. We combined behavioral studies w...

Fatty Acid Amide Hydrolase-Dependent Generation of Antinociceptive Drug Metabolites Acting on TRPV1 in the Brain

Archive ouverte | Barrière, David, A | CCSD

International audience. The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Zeicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's a...

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