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The Staphylococcus aureus FASII bypass escape route from FASII inhibitors

Archive ouverte | Morvan, Claire | CCSD

International audience. Antimicrobials targeting the fatty acid synthesis (FASII) pathway are being developed as alternative treatments for bacterial infections. Emergence of resistance to FASII inhibitors was mainl...

Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments

Archive ouverte | Kénanian, Gérald | CCSD

International audience. The essentiality of fatty acid synthesis (FASII) prod-ucts in the human pathogenStaphylococcus aureusis the underlying rationale for FASII-targeted antimi-crobial drug design. Reports of anti...

Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials

Archive ouverte | Morvan, Claire | CCSD

International audience. The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. This strategy is based on previous reports indicating that self-synthes...

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