Can a failure in the error-monitoring system explain unawareness of memory deficits in Alzheimer’s disease?

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Razafimahatratra, Solofo | Guieysse, Thomas | Lejeune, François-Xavier | Houot, Marion | Medani, Takfarinas | Dreyfus, Gérard | Klarsfeld, André | Villain, Nicolas | Pereira, Filipa Raposo | La Corte, Valentina | George, Nathalie | Pantazis, Dimitrios | Andrade, Katia

Edité par CCSD ; Elsevier -

International audience. Error-monitoring system Neural mechanism error awareness, was observed in the PROG group at the time of AD diagnosis (vs study entry) in intra-group analysis, as well as when compared with the CTRL group in intergroup analysis, based on the last EEG acquisition for all subjects. Importantly, at the time of AD diagnosis, the PROG group exhibited clinical signs of anosognosia, overestimating their cognitive abilities, as evidenced by the discrepancy scores obtained from caregiver/informant vs participant reports on the cognitive subscale of the Healthy Aging Brain Care Monitor. To our knowledge, this is the first study to reveal the emergence of a failure in the error-monitoring system during a word memory recognition task at the early stages of AD. This finding, along with the decline of awareness for cognitive impairment observed in the PROG group, strongly suggests that a synaptic dysfunction in the errormonitoring system may be the critical neural mechanism at the origin of unawareness of deficits in AD.

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