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NMR Metabolomics Profiling Reveals Distinctive Signatures of an Obesogenic Diet in Mice. NMR Metabolomics Profiling Reveals Distinctive Signatures of an Obesogenic Diet in Mice: Uncovering Metabolite Signatures in Six Organs During a High-Fat, High-Sucrose Diet: A Cross-Sectional NMR Metabolomics Study

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Drevet Mulard, Eva | Guibert, Sylvie | Lefevre, C. | Chauvin, M.A. | Pinteur, Claudie | Monet, M.A. | Godet, M. | Madec, A.M. | Morio, Béatrice | Rieusset, J. | Anne, Mey | Rautureau, Gilles J.P. | Panthu, Baptiste

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International audience. Obesity is a significant risk factor for diseases like type 2 diabetes and cardiovascular disorders. Identifying biomarkers for early obesity-related disorders is crucial for precision medicine. We used NMR to analyze metabolomic profiles of key organs and serum in male C57Bl/6J mice fed a high-fat, high-sucrose diet (HFHSD, 36 % w/w fat, 16.6 % w/w sucrose, Envigo, France) or standard diet (STD, Rhod16A, Genobio) for 6, 10, and 14 weeks. Our study reveals organ-specific metabolite concentrations, highlighting age and diet effects and their interaction.

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