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Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma

Archive ouverte | Bruyer, Angélique | CCSD

International audience. Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clonal proliferation of malignant plasma cells. Despite the introduction of novel agents that have significant...

Comprehensive characterization of the epigenetic landscape in Multiple Myeloma

Archive ouverte | Alaterre, Elina | CCSD

International audience. Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to understand the molecular processes that drive MM biology. Epigenetic modifications are involved in MM devel...

RNA-Sequencing-Based Transcriptomic Score with Prognostic and Theranostic Values in Multiple Myeloma

Archive ouverte | Alaterre, Elina | CCSD

International audience. Multiple myeloma (MM) is the second most frequent hematological cancer and is characterized by the clonal proliferation of malignant plasma cells. Genome-wide expression profiling (GEP) analy...

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