Suggestions

Du même auteur

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Archive ouverte | Cook, Nicola | CCSD

International audience. Strengths and weaknesses of an HIV drug Retroviruses replicate by inserting a copy of their RNA, which has been reverse transcribed into DNA, into the host genome. This process involves the i...

A supramolecular assembly mediates lentiviral DNA integration

Archive ouverte | Ballandras-Colas, Allison | CCSD

International audience. High-resolution insights into the intasome An essential step in the life cycle of lentiviruses such as HIV-1 is when viral DNA integrates into the host genome, establishing a permanent infect...

B-to-A transition in target DNA during retroviral integration

Archive ouverte | Jóźwik, Ilona | CCSD

International audience. Abstract Integration into host target DNA (tDNA), a hallmark of retroviral replication, is mediated by the intasome, a multimer of integrase (IN) assembled on viral DNA (vDNA) ends. To ascert...

Chargement des enrichissements...