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Consistency of Mycobacterium tuberculosis Complex Spoligotyping between the Membrane-Based Method and In Silico Approach

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Genestet, Charlotte | Hodille, Elisabeth | Bernard, Albin | Vallée, Maxime | Lina, Gérard | Le Meur, Adrien | Refrégier, Guislaine | Dumitrescu, Oana

Edité par CCSD ; American Society for Microbiology -

International audience. Whole-genome sequencing (WGS) has profoundly transformed the perspectives of tuberculosis (TB) diagnosis, providing a better discriminatory power to determine relatedness between Mycobacterium tuberculosis complex (MTBC) isolates. Previous genotyping approaches, such as spoligotyping consisting of an initial PCR step followed by reverse dot hybridization, are currently being replaced by WGS.

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