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C57BL/6 congenic mouse NRAS Q61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo

Archive ouverte | Petit, Valérie | CCSD

International audience. RAS is frequently mutated in various tumors and known to be difficult to target. NRASQ61K/R are the second most frequent mutations found in human skin melanoma after BRAFV600E . Aside from su...

The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma

Archive ouverte | Raymond, Jérémy | CCSD

International audience. Summary Although tremendous progress has been made in understanding the mechanisms leading to cancer, those governing metastases are still poorly understood. E-cadherin (Ecad) is a cell-cell ...

BRN2 is a non-canonical melanoma tumor-suppressor

Archive ouverte | Hamm, Michael | CCSD

International audience. While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered t...

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