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Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model

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Iturri, Lorea | Bertho, Annaïg | Lamirault, Charlotte | Juchaux, Marjorie | Gilbert, Cristèle | Espenon, Julie | Sebrie, Catherine | Jourdain, Laurène | Pouzoulet, Frédéric | Verrelle, Pierre | de Marzi, Ludovic | Prezado, Yolanda

Edité par CCSD ; Elsevier -

International audience. FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT has been observed to provide normal tissue sparing at high dose rates and similar tumor control compared with conventional RT, yet the biological processes governing these radiobiological effects are still unknown. In this study, we sought to investigate the potential immune response generated by FLASH-RT in a high dose of proton therapy in an orthotopic glioma rat model.

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