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Thermodynamics and Mechanism of Action of a Series of Organoruthenium Anticancer Reagents

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Ali, Moussa | Boff, Bastien | Issenhuth, Jean-Thomas | Boos, Anne | Potier, Noëlle | Harlepp, Sebastien | Loeffler, Jean-Philippe | Sirlin, Claude

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Antiproliferative effects on HCT-116 and U-87 cells by a series of organoruthenium complexes have been determined. Redox properties have been measured as well. The highlighted binomial relationship between the biological activity and the oxidation potentials was interpreted as two competitive reactions of oxidation and reduction of the metallic centre. The oxidation of Ru (II) in Ru (III) complexes presumably by oxygen has been observed by UV-vis spectrophotometry and mass spectrometry. The reduction ofRu (III) in Ru (II) complexes is performed by reducing compounds from the cell (observed with glucose).

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