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Impact of EGFRA289T/V mutation on relapse pattern in glioblastoma

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Noeuveglise, A. | Sarafan-Vasseur, N. | Beaussire, L. | Marguet, F. | Modzelewski, R. | Hanzen, C. | Alexandru, C. | Magne, N. | Langlois, O. | Di Fiore, F. | Clatot, F. | Thureau, S. | Fontanilles, M.

Edité par CCSD ; European Society for Medical Oncology -

International audience. Molecular factors influence relapse patterns in glioblastoma. The hotspot mutation located at position 289 of the extracellular domain of the epidermal growth factor receptor (EGFRA289mut) is associated with a more infiltrative phenotype. The primary objective of this study was to explore the impact of the EGFRA289 mutation on the pattern of relapse after chemoradiotherapy-based treatment of patients suffering from newly diagnosed glioblastoma.

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