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Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization

Archive ouverte | Nora, Elphege, P | CCSD

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understood. The transcription factor CTCF is a candidate regulator of chromosomal structure. Using the auxin-inducible degron system in mouse embry...

Heterogeneity and Intrinsic Variation in Spatial Genome Organization

Archive ouverte | Finn, Elizabeth | CCSD

Abstract The genome is hierarchically organized in 3D space and its architecture is altered in differentiation, development and disease. Some of the general principles that determine global 3D genome organization have been establi...

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization

Archive ouverte | Finn, Elizabeth | CCSD

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