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Combining μX-ray fluorescence, μXANES and μXRD to shed light on Zn2+ cations in cartilage and meniscus calcifications

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Dessombz, Arnaud | Nguyen, Christelle | Ea, Hang-Korng | Rouzière, Stephan | Foy, Eddy | Hannouche, Didier | Réguer, Solene | Picca, Frederic-Emmanuel | Thiaudière, Dominique | Lioté, Frédéric | Daudon, Michel | Bazin, Dominique

Edité par CCSD ; Elsevier -

International audience. We aimedtoexaminethepresenceofZn,atraceelement,inosteoarthritis(OA)cartilageandmeniscusfrom patientsundergoingtotalkneejointreplacementforprimaryOA.WemappedCa2+ and Zn2+ at themesoscopic scalebyX-rayfluorescencemicroanalysis(X-ray) todeterminethespatialdistributionofthe 2elementsincartilage,X-ray absorptionnearedgestructurespectroscopytoidentifytheZnspecies,and X-ray diffractiontodeterminethechemicalnatureofthecalcification.Fouriertransforminfraredspectroscopy wasusedtodeterminethechemicalcompositionofcartilageandmeniscus.Ca2+ showeda heterogeneousspatialdistributioncorrespondingtothecalcificationswithincartilage(ormeniscus)or attheirsurface.Atleast2Zn2+ species werepresent:thefirstmaycorrespondtoZnembeddedinprotein (differentZnmetalloproteinsareknowntopreventcalcificationinbiologicaltissues),andthesecond maybeassociatedwithaZntrapinoratthesurfaceofthecalcification.CalcificationpresentinOA cartilagemaysignificantlymodifythespatialdistributionofZn;partoftheZnmaybetrappedinthecalcification andmayaltertheassociatedbiologicalfunctionofZnmetalloproteins.

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