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Morphological control enables nanometer-scale dissection of cell-cell signaling complexes

Archive ouverte | Dow, Liam | CCSD

International audience. Protein micropatterning enables robust control of cell positioning on electron-microscopy substrates for cryogenic electron tomography (cryo-ET). However, the combination of regulated cell bo...

Structural basis of αE-catenin–F-actin catch bond behavior

Archive ouverte | Xu, Xiao-Ping | CCSD

International audience. Cell-cell and cell-matrix junctions transmit mechanical forces during tissue morphogenesis and homeostasis. α-Catenin links cell-cell adhesion complexes to the actin cytoskeleton, and mechani...

ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells

Archive ouverte | Kai, Fuiboon | CCSD

Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stres...

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