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Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

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Durier, Christine | Ninove, Laetitia | Lefebvre, Maeva | Radenne, Anne | Desaint, Corinne | Ropers, Jacques | Bauer, Rebecca | Lebbah, Said | Carette, Diane | Lachâtre, Marie | Lecompte, Anne-Sophie | Deplanque, Dominique | Botelho-Nevers, Elisabeth | Conrad, Anne | Dussol, Bertrand | Maakaroun-Vermesse, Zoha | Melica, Giovanna | Nicolas, Jean-François | Verdon, Renaud | Kiladjian, Jacques | Loubet, Paul | Schmidt-Mutter, Catherine | Dualé, Christian | Ansart, Séverine | Priet, Stéphane | Levier, Axel | Molino, Diana | Vieillard, Louis-Victorien | Parfait, Béatrice | Lelièvre, Jean-Daniel | Tartour, Eric | de Lamballerie, Xavier | Launay, Odile | Mchantaf, Gilbert | Imbert-Marcille, Berthe-Marie | Montagne, Samantha | Ghaleh-Marzban, Bijan | Traverse-Glehen, Alexandra | Vivien, Denis | Cassinat, Bruno | Evrard, Alexandre | Metzger, Catherine | Lessinger, Jean-Marc | Billing, Michel | Berger, Marc | Leroyer, Christophe | Appay, Victor | Batteux, Frédéric | Combadière, Béhazine | Gorochov, Guy | Paul, Stéphane | van Der Werf, Sylvie | Eberhardt, Christiane | Siegrist, Claire-Anne | Cogné, Michel | Pellegrin, Isabelle | Eloit, Marc | Netzer, Emmanuelle | Resch, Martine | Saouzanet, Marine | Meyer, Laurence | Bonneton, Marion | Tardieu, Raphaelle | Le Mestre, Soizic | Jancrey-Laval, Solange | Petrov-Sanchez, Ventzislava | Rosenthal, Eric | Yazdanpanah, Yazdan | Olive, Daniel | Bouakane, Amel | Rieux, Véronique | Madelaine, Claire | Diallo, Alpha | Valour, Florent | Hisbergues, Michael | Bertholon, Frederique | Icard, Vinca | de Sandre-Giovannoli, Annachiara | Dropy, Margot | Bouchama, Fatiha | Thamri, Mehdi | Azimi, Shorheh

Edité par CCSD ; Nature Publishing Group -

International audience. Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.

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