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Proposition d’un modèle transgénique murin (APPxM83) développant une pathologie associée à la co-expression des protéines alpha-synucléine et β-amyloïde humaines »

Archive ouverte | Arsac, Jean-Noël | CCSD

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Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein

Archive ouverte | Bétemps, Dominique | CCSD

International audience. Human neurodegenerative diseases associated with the misfolding of the alpha-synuclein (aS) protein (synucleinopathies) are similar to prion diseases to the extent that lesions are spread by ...

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA

Archive ouverte | Bétemps, Dominique | CCSD

International audience. The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson's disease (PD) or de...

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