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PML/RARα Destabilization by Hyperthermia: A New Model for Oncogenic Fusion Protein Degradation?

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Wu, Hsin Chieh | Rérolle, Domitille | de Thé, Hugues

Edité par CCSD ; American Association for Cancer Research -

International audience. In this issue, Maimaitiyiming and colleagues demonstrate thermic stress–induced PML/RARα oncogenic fusion protein destabilization driven by corepressor aggregation. Hyperthermia synergizes with PML/RARα degradation by arsenic trioxide (ATO) and may circumvent ATO-resistance in historic acute promyelocytic leukemia patients. This novel approach could be extended to other corepressor-associated oncogenic fusion proteins. See related article by Maimaitiyiming et al., p. 388.

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