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CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1.

Archive ouverte | Taverniti, Valerio | CCSD

Background & Aims Chronic HBV infection is the leading cause of liver disease and of hepatocellular carcinoma. The improvement of antiviral therapy remains an unmet medical need. Capsid assembly modulators (CAMs) target the HB...

Class a capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.

Archive ouverte | Kum, Dieudonné Buh | CCSD

Effective therapies leading to a functional cure of chronic hepatitis B (CHB) are still lacking. Class A capsid assembly modulators (CAM-As) are an attractive modality to address this unmet medical need. CAM-As induce aggregation ...

Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.

Archive ouverte | Vanrusselt, Hannah | CCSD

Chronic hepatitis B is the most important cause of liver cancer worldwide and affects more than 290 million people. Current treatments are mostly suppressive and rarely lead to a cure. Therefore, there is a need for novel and cura...

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