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The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway

Archive ouverte | Bavencoffe, Alexis | CCSD

International audience. The transient receptor potential channel melastatin member 8 (TRPM8) is expressed in sensory neurons, where it constitutes the main receptor of environmental innocuous cold (10-25°C). Among s...

Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity

Archive ouverte | Gkika, Dimitra | CCSD

International audience. Recent studies have revealed gender differences in cold perception, and pointed to a possible direct action of testosterone (TST) on the cold-activated TRPM8 (Transient Receptor Potential M...

TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Archive ouverte | Gkika, Dimitra | CCSD

International audience. In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa progression beca...

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