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Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

Archive ouverte | Touhami, Sara | CCSD

International audience. BackgroundThe retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye. We have previously shown that acute stimul...

IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis

Archive ouverte | Charles-Messance, Hugo | CCSD

International audience. Background: Age-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mo...

The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination

Archive ouverte | Beguier, Fanny | CCSD

International audience. A minor haplotype of the 10q26 locus conveys the strongest genetic risk for age-related macular degeneration (AMD). Here, we examined the mechanisms underlying this susceptibility. We found t...

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