High prevalence of myeloid neoplasms in adults with non–Langerhans cell histiocytosis

Archive ouverte

Papo, Matthias | Diamond, Eli | Cohen-Aubart, Fleur | Emile, Jean-François | Roos-Weil, Damien | Gupta, Nishant | Durham, Benjamin | Ozkaya, Neval | Dogan, Ahmet | Ulaner, Gary | Rampal, Raajit | Kahn, Jean-Emmanuel | Sené, Thomas | Charlotte, Frédéric | Hervier, Baptiste | Besnard, Caroline | Bernard, Olivier | Settegrana, Catherine | Droin, Nathalie | Hélias-Rodzewicz, Zofia | Amoura, Zahir | Abdel-Wahab, Omar | Haroche, Julien

Edité par CCSD ; American Society of Hematology -

International audience. Key Points Some 10.1% of adults with non–Langerhans cell histiocytosis have a concomitant myeloid neoplasm with each often harboring distinct mutations. The presence of distinct kinase mutations in histiocytosis and myeloid neoplasms resulted in discordant responses to targeted therapy.

Consulter en ligne

Suggestions

Du même auteur

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

Archive ouverte | Durham, Benjamin | CCSD

International audience. Langerhans cell histiocytosis (LCH) and the non-LCH neoplasm Erdheim-Chester disease (ECD) are heterogeneous neoplastic disorders marked by infiltration of pathologic macrophage-, dendritic c...

High frequency of clonal hematopoiesis in Erdheim-Chester disease

Archive ouverte | Cohen Aubart, Fleur | CCSD

International audience. Abstract Erdheim-Chester disease (ECD) is a clonal hematopoietic disorder characterized by the accumulation of foamy histiocytes within organs (in particular, frequent retroperitoneal involve...

Risk of Second Cancer in Erdheim-Chester Disease

Archive ouverte | Pegoraro, Francesco | CCSD

International audience. This cohort study analyzes the risk of second cancers in a cohort of 515 patients with Erdheim-Chester disease followed up at 2 histiocytosis centers in France and Italy.

Chargement des enrichissements...