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A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production

Archive ouverte | Gautier-Stein, Amandine | CCSD

International audience. Objective: Deregulation of hepatic glucose production is a key driver in the pathogenesis of diabetes, but its short-term regulation is incompletely deciphered. According to textbooks, glucos...

The role of kidney in the inter-organ coordination of endogenous glucose production during fasting

Archive ouverte | Kaneko, Keizo | CCSD

International audience. OBJECTIVE:The respective contributions to endogenous glucose production (EGP) of the liver, kidney and intestine vary during fasting. We previously reported that the deficiency in either hepa...

Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1α With CREB-Binding Protein.. Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1α With CREB-Binding Protein.: Glucotoxicity induces HIF-1 transcriptional activity

Archive ouverte | Gautier-Stein, Amandine | CCSD

International audience. The activation of glucose-6-phosphatase (G6Pase), a key enzyme of endogenous glucose production, is correlated with type 2 diabetes. Type 2 diabetes is characterized by sustained hyperglycemi...

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