Afficher la couverture 'The TBP-like factor: an alternative transcription factor in metazoa? | Dantonel, Jean-Christophe' en grand format
/5

0 avis

The TBP-like factor: an alternative transcription factor in metazoa?

Archive ouverte

Dantonel, Jean-Christophe | Wurtz, Jean-Marie | Poch, Olivier | Moras, Dino | Tora, Laszlo

Edité par CCSD ; Elsevier -

International audience. Protein sequence analysis has revealed a family of TATA-binding-protein (TBP)-like factors (TLFs) in metazoan organisms. Modelling of the three-dimensional structure of these TLFs suggests that they form an asymmetric saddle-like structure and that, unlike TBP, TLFs might bind to DNA sequences other than classical TATA boxes. Thus, the existence of TLFs presents a challenge to the doctrine that TBP is a universal regulator of transcription in metazoans.

Consulter en ligne

Suggestions

Du même auteur

TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans

Archive ouverte | Dantonel, Jean-Christophe | CCSD

Recently, a novel family of TATA binding protein (TBP)-like factors (TLFs) have been described in metazoan organisms; however, their function has not yet been elucidated. Using Caenorhabditis elegans (Ce) as a model, we demonstrat...

TBP is not universally required for zygotic RNA polymerase II transcription in zebrafish

Archive ouverte | Müller, Ferenc | CCSD

General transcription factors TFIIA, B, D, E, F, H, and RNA polymerase II (Pol II) are required for accurate initiation of Pol II transcription. The TATA binding protein (TBP), a subunit of TFIID, is responsible for recognition of...

Quantitative Cell-Based Reporter Gene Assays Using Droplet-Based Microfluidics

Archive ouverte | Baret, Jean-Christophe | CCSD

International audience

Chargement des enrichissements...