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Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa: Results of the GERPA Multicenter Study

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Fournier, Damien | Carrière, Romain | Bour, Maxime | Grisot, Emilie | Triponney, Pauline | Muller, Cédric | Lemoine, Jérôme | Jeannot, Katy | Plésiat, Patrick

Edité par CCSD ; American Society for Microbiology -

International audience. Resistance mechanisms of Pseudomonas aeruginosa to ceftolozane/tazobactam (C/T) were assessed on a collection of 420 nonredundant strains nonsusceptible to ceftazidime (MIC > 8 μg/ml) and/or imipenem (>4 μg/ml), collected by 36 French hospital laboratories over a one-month period (the GERPA study). Rates of C/T resistance (MIC > 4/4 μg/ml) were equal to 10% in this population (42/420 strains), and 23.2% (26/112) of the isolates were resistant to both ceftazidime and imipenem.

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