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Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension

Archive ouverte | Lambert, Mélanie | CCSD

International audience. Aims: Mutations in the KCNK3 gene, which encodes for an outward-rectifier K+ channel, have been identified in patients suffering from pulmonary arterial hypertension (PAH), and constitute the...

Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload

Archive ouverte | Mendes-Ferreira, Pedro | CCSD

International audience. Pulmonary hypertension (PH) is a common complication of left heart disease (LHD, Group 2 PH) leading to right ventricular (RV) failure and death. Several loss-of-function (LOF) mutations in K...

Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension

Archive ouverte | Hautefort, Aurélie | CCSD

International audience. Background: Monoallelic mutations in the gene encoding bone morphogenetic protein receptor 2 ( Bmpr2 ) are the main genetic risk factor for heritable pulmonary arterial hypertension (PAH) wit...

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