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RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

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Schneider, Anne, T | Gautheron, Jérémie | Feoktistova, Maria | Roderburg, Christoph | Loosen, Sven, H | Roy, Sanchari | Benz, Fabian | Schemmer, Peter | Büchler, Markus, W | Nachbur, Ueli | Neumann, Ulf, P | Tolba, Rene | Luedde, Mark | Zucman-Rossi, Jessica | Panayotova-Dimitrova, Diana | Leverkus, Martin | Preisinger, Christian | Tacke, Frank | Trautwein, Christian | Longerich, Thomas | Vucur, Mihael | Luedde, Tom

Edité par CCSD ; Elsevier -

International audience. Highlights d RIPK1 ablation induces TNF-mediated hepatocyte apoptosis without affecting NF-kB d Loss of RIPK1 leads to proteasomal TRAF2 degradation in a kinase-independent manner d RIPK1 and TRAF2 act together to prevent spontaneous HCC development d Low expression of TRAF2 and RIPK1 in human HCC predicts poor prognosis

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