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[Study of the determinism of diffuse interstitial lung disease associated with rheumatoid arthritis] : [genetic and environmental susceptibility factors]. Étude du déterminisme des pneumopathies interstitielles diffuses associées à la polyarthrite rhumatoïde : facteurs de susceptibilité génétiques et environnementaux

Archive ouverte | Juge, Pierre-Antoine | CCSD

Interstitial lung disease (ILD) is a severe extra articular manifestation of rheumatoid arthritis (RA) associated with an increased mortality rate. A symptomatic clinical ILD is observed in about 10% of patients with RA but inters...

Variants of genes implicated in type 1 interferon pathway and B-cell activation modulate the EULAR response to rituximab at 24 weeks in rheumatoid arthritis

Archive ouverte | Juge, Pierre-Antoine | CCSD

BACKGROUND: The type 1 interferon (IFN) pathway has been identified to potentially affect the response to rituximab (RTX) for rheumatoid arthritis (RA), which suggests the contribution of type 1 IFN pathway genes such as IFN regul...

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

Archive ouverte | Juge, Pierre-Antoine | CCSD

International audience. BACKGROUND: Given the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesiz...

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