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Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos

Archive ouverte | Lo Furno, Elena | CCSD

International audience. In early embryogenesis of fast cleaving embryos, DNA synthesis is short and surveillance mechanisms preserving genome integrity are inefficient, implying the possible generation of mutations....

Role of RPA as sensor in activation of the S-phase checkpoint in Xenopus egg extracts

Archive ouverte | Recolin, Bénédicte | CCSD

International audience. Uncoupling between DNA polymerases and helicase activities at replication forks, induced by diverse DNA lesions or replication inhibitors, generate long stretches of primed single-stranded DN...

RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos

Archive ouverte | Kermi, Chames | CCSD

International audience. In early embryos, the DNA damage checkpoint is silent until the midblastula transition (MBT) because of maternal limiting factors of unknown identity. Here we identify the RAD18 ubiquitin lig...

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