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Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock

Archive ouverte | Laterre, Pierre-François | CCSD

International audience. Importance: Norepinephrine, the first-line vasopressor for septic shock, is not always effective and has important catecholaminergic adverse effects. Selepressin, a selective vasopressin V1a ...

Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial. Évaluation prospective de l'efficacité, de la sécurité et de la stratégie optimale d'enrichissement des biomarqueurs pour le nangibotide, un inhibiteur de TREM-1, chez les patients en état de choc septique (ASTONISH) : un essai de phase 2b en double aveugle, randomisé et contrôlé

Archive ouverte | François, Bruno | CCSD

International audience. SummaryBackgroundActivation of the triggering receptor expressed on myeloid cells-1 (TREM-1) pathway is associated with septic shock outcomes. Data suggest that modulation of this pathway in ...

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19

Archive ouverte | Florescu, Simin | CCSD

International audience. Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain.Objective To determine whether antiplatelet therapy improves outcomes for critically il...

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