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The dynamical Matryoshka model: 3. Diffusive nature of the atomic motions contained in a new dynamical model for deciphering local lipid dynamics
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International audience. In accompanying papers [Bicout et al., BioRxiv https://doi.org/10.1101/2021.09.21.461198 (2021); Cissé et al.,BioRxiv https://doi.org/10.1101/2022.03.30.486370 (2022)], a new model called Matryoshka model has beenproposed to describe the geometry of atomic motions in phospholipid molecules in bilayers and multilamellarvesicles based on their quasielastic neutron scattering (QENS) spectra. Here, in order to characterize therelaxational aspects of this model, the energy widths of the QENS spectra of the samples were analyzed first in amodel-free way. The spectra were decomposed into three Lorentzian functions, which are classified as slow,intermediate, and fast motions depending on their widths. The analysis provides the diffusion coefficients,residence times, and geometrical parameters for the three classes of motions. The results corroborate theparameter values such as the amplitudes and the mobile fractions of atomic motions obtained by the applicationof the Matryoshka model to the same samples. Since the current analysis was carried out independently of thedevelopment of the Matryoshka model, the present results enhance the validity of the model. The model willserve as a powerful tool to decipher the dynamics of lipid molecules not only in model systems, but also in morecomplex systems such as mixtures of different kinds of lipids or natural cell membranes.
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