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RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5

Archive ouverte | Cayre, Surya | CCSD

International audience. The Golgi-associated RAB GTPases, RAB6A and RAB6A′, regulate anterograde and retrograde transport pathways from and to the Golgi. In vitro, RAB6A/A′ control several cellular functions includi...

The recycling endosome biogenesis machinery coordinates BACE1 endosomal sorting and amyloid-β production

Archive ouverte | Brault, Jean-Baptiste | CCSD

International audience. Abstract Alzheimer’s disease (AD) is the most common form of dementia worldwide. One of AD’s main pathological hallmarks is the cerebral plaque deposits of β-amyloid (Aβ). Aβ is generated thr...

Rab6-interacting protein 1 links Rab6 and Rab11 function.

Archive ouverte | Miserey-Lenkei, Stéphanie | CCSD

Rab11 and Rab6 guanosine triphosphatases are associated with membranes of the recycling endosomes (REs) and Golgi complex, respectively. Evidence indicates that they sequentially regulate a retrograde transport pathway between the...

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