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Lipoplexes Strengthened by Anionic Polymers: Easy Preparation of Highly Effective siRNA Vectors Based on Cationic Lipids and Anionic Polymers

Archive ouverte | Arruda, Danielle Campiol | CCSD

International audience. RNA interference is an invaluable tool in biology to specifically silence a given gene. Synthetic duplexes of RNA oligonucleotides are widely used to induce mRNA degradation in cultured cells...

Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet form

Archive ouverte | Busignies, Virginie | CCSD

International audience. Currently, most nonviral nucleic acid vectors are in the form of colloidal suspensions administered primarily parenterally. This type of formulation and the mode of administration impose stro...

Spheroplexes: Hybrid PLGA-cationic lipid nanoparticles, for in vitro and oral delivery of siRNA

Archive ouverte | Arruda, Danielle Campiol | CCSD

International audience. Vectorized small interfering RNAs (siRNAs) are widely used to induce gene silencing. Among the delivery systems used, lipid-based particles are the most effective. Our objective was the devel...

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