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Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model

Archive ouverte | Di Franco, Nadia | CCSD

International audience. Down syndrome (DS) or Trisomy 21 is the most common genetic cause of mental retardation with severe learning and memory deficits. DS is due to the complete or partial triplication of human ch...

Functional heterogeneity of POMC neurons relies on mTORC1 signaling

Archive ouverte | Saucisse, Nicolas | CCSD

International audience. Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), gl...

Hypothalamic bile acid-TGR5 signaling protects from obesity

Archive ouverte | Castellanos-Jankiewicz, Ashley | CCSD

International audience. Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the br...

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