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Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells

Archive ouverte | Mastelic-Gavillet, Beatris | CCSD

International audience. Background Several mechanisms are present in the tumor microenvironment (TME) to impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the accumulation of a...

Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints

Archive ouverte | Gourdin, Nicolas | CCSD

International audience. The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ecton...

CD73 expression in normal and pathological human hepatobiliopancreatic tissues

Archive ouverte | Sciarra, Amedeo | CCSD

International audience. Background: The tumor-expressed CD73 ectonucleotidase generates immune tolerance and promotes invasiveness via adenosine production from degradation of AMP. While anti-CD73 blockade treatment...

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