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Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization

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Su, Yangyang | Hessou, Etienne | Colombo, Estefania | Belletti, Gustavo | Moussadik, Ali | Lucas, Ivan T. | Frochot, Vincent | Daudon, Michel | Rouzière, Stéphan | Bazin, Dominique | Li, Kezhi | Quaino, Paola | Tielens, Frederik

Edité par CCSD ; Springer Verlag -

International audience. It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate L-cystine crystals. Recently, the presence of L-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([-S-CH2-CH-(NH2)-COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S-S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between L-cystine and L-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.

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