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A unique peptide deformylase platform to rationally design and challenge novel active compounds

Archive ouverte | Fieulaine, Sonia | CCSD

International audience. Abstract Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agala...

A unique peptide deformylase platform to rationally design and challenge novel active compounds

Archive ouverte | Fieulaine, Sonia | CCSD

International audience. Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, sh...

New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity.

Archive ouverte | Goemaere, Emilie | CCSD

International audience. OBJECTIVES: Bacterial drug resistance is a worrying public health problem and there is an urgent need for research and development to provide new antibacterial molecules. Peptide deformylase ...

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