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Structural model of ligand-G Protein-coupled Receptor (GPCR) complex based on experimental double mutant cycle data

Archive ouverte | Marquer, Catherine | CCSD

International audience. The snake toxin MT7 is a potent and specific allosteric modulator of the human M1 muscarinic receptor (hM1). We previously characterized by mutagenesis experiments the functional determinants...

Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the α1A-adrenoceptor

Archive ouverte | Quinton, L. | CCSD

International audience. BACKGROUND AND PURPOSE:Venoms are a rich source of ligands for ion channels, but very little is known about their capacity to modulate G-protein coupled receptor (GPCR) activity. We developed...

Muscarinic toxins

Archive ouverte | Servent, Denis | CCSD

International audience. Muscarinic toxins isolated from the venom of Dendroaspis snakes may interact with a high affinity, large selectivity and various functional properties with muscarinic receptors. Therefore, th...

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