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Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

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Tuloup, Vianney | France, Mathilde | Garreau, Romain | Bleyzac, Nathalie | Bourguignon, Laurent | Tod, Michel | Goutelle, Sylvain

Edité par CCSD ; American Society for Microbiology -

International audience. Rifamycins are widely used for treating mycobacterial and staphylococcal infections. Drug-drug interactions (DDI) caused by rifampicin (RIF) are a major issue. We used a model-based approach to predict the magnitude of DDI with RIF and rifabutin (RBT) for 217 cytochrome P450 (CYP) substrates. On average, DDI caused by low-dose RIF were twice as potent as those caused by RBT. Contrary to RIF, RBT appears unlikely to cause severe DDI, even with sensitive CYP substrates.

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