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More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

Archive ouverte | Ferdousi, Leyla Vahidi | CCSD

International audience. The loss of genome integrity in adult stem cells results in accelerated tissue aging and is possibly cancerogenic. Adult stem cells in different tissues appear to react robustly to DNA damage...

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

Archive ouverte | Schellenbauer, Amelie | CCSD

International audience. Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of Ku70 at ser27-se...

Implication of DNA damage and repair in viability and differentiation of muscle stem cells. Implication des dommages à l’ADN et leur réparation sur la viabilité et la différentiation des cellules souches musculaires

Archive ouverte | Sutcu, Haser | CCSD

DNA double-strand breaks (DSBs) are dangerous DNA damages and a risk factor for genome stability. The maintenance of genome integrity is crucial for adult stem cells that are responsible for regeneration of damaged tissues and tis...

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