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Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons

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International audience. G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery of drugs targeting these receptors and their G protein sig...

Structures of human mGlu2 and mGlu7 homo- and heterodimers

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International audience. The metabotropic glutamate receptors (mGlus) are involved in the modulation of synaptic transmission and neuronal excitability in the central nervous system1. These receptors probably exist a...

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Archive ouverte | Shen, Cangsong | CCSD

International audience. G-protein-coupled receptors (GPCRs) have central roles in intercellular communication1,2. Structural studies have revealed how GPCRs can activate G proteins. However, whether this mechanism i...

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