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The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

Archive ouverte | Haarhuis, Judith H.I. | CCSD

International audience. The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes....

Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells

Archive ouverte | Amendola, Mario | CCSD

PMC4428043. International audience. In mammals, the nuclear lamina interacts with hundreds of large genomic regions, termed lamina-associated domains (LADs) that are generally in a transcriptionally repressed state....

CHRAC/ACF contribute to the repressive ground state of chromatin

Archive ouverte | Scacchetti, Alessandro | CCSD

International audience. The chromatin remodeling complexes chromatin accessibility complex and ATP-utilizing chromatin assembly and remodeling factor (ACF) combine the ATPase ISWI with the signature subunit ACF1. Th...

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