Syracuse

Uncovering the Importance of Selenium in Muscle Disease

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Lescure, Alain | Baltzinger, Mireille | Zito, Ester

Edité par CCSD ; Springer International Publishing -

International audience. A connection between selenium bioaviability and the development of muscular disorders both in humans and livestock has been established for a long time. With the development of genomics, the function of several selenoproteins was shown to be involved in muscle activity, including SELENON, which was linked to an inherited form of myopathy. Development of animal models has helped to dissect the physiological dysfunction due to mutation in the SELENON gene, however the molecular activity remains elusive and only recent analysis using both in vivo and in vitro experiment provided hints toward its function in oxidative stress defense and calcium transport control. This review sets out to summarize most recent findings for the importance for selenium in muscle function and the contribution of this information to the design of strategies to cure the diseases.

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